Réaction #41965

Équation de réaction

triphenylphosphine

3-bromopropionic acid

ether

→

title compound

Rendement 68.5%

(2-Carboxy-ethyl)-triphenyl-phosphonium bromide

Rendement 68.5%

Solvants

acetonitrile

Conditions de réaction

Traitement

1. 1
   FiltrationFilter solids
2. 2
   Lavagerinse with ether
3. 3
   Autredry solids under high vacuum

Mode opératoire

Reflux a solution of triphenylphosphine (91.3 g, 348 mmol, 1.05 equivalents) and 3-bromopropionic acid (50.7 g, 331 mmol) in acetonitrile (250 ml) for three hours, allow to sit at room temperature overnight. Add ether (400 ml) and cool in the freezer for two hours. Filter solids, rinse with ether, and dry solids under high vacuum to obtain the title compound (94.1 g, 68%). NMR (400 MHz, CDCl3): δ 3.15 (m, 2H), 3.73 (m, 2H), 7.69-7.83 (m, 15H).

Source