Réaction #417972

Équation de réaction

Water

compound 26a

2-(3-bromo-propoxy)-1-chloro-4-nitro benzene

N-phenyl piperazine

potassium carbonate

→

title compound 26b

Rendement 78.0%

1-[3-(2-chloro-5-nitro-phenoxy)-propyl]-4-phenyl-piperazine

Rendement 78.0%

Solvants

DMF

Conditions de réaction

Traitement

1. 1
   Autreat room temperature
2. 2
   Extractionextracted with ethyl acetate (3×20 mL)
3. 3
   SéchageThe combined extracts were dried over sodium sulfate
4. 4
   Concentrationconcentrated under reduced pressure
5. 5
   AutreThe crude product was purified by flash column chromatography

Mode opératoire

To the compound 26a (2.1 g, 7.1 mmol) in DMF (9 mL) was added N-phenyl piperazine (1.16 g, 7.1 mmol) and potassium carbonate (1.28 g, 9.23 mmol). The mixture was stirred for 18 hrs. at room temperature. Water (10 mL) was added to the reaction mixture and extracted with ethyl acetate (3×20 mL). The combined extracts were dried over sodium sulfate and concentrated under reduced pressure. The crude product was purified by flash column chromatography to get the title compound 26b in 78% yield as yellow solid.

Source