Réaction #417966

ord-a850d830de6642eabd903b98dc6331d2

Équation de réaction

COc1ccc(N)cc1O
5-amino-2-methoxy phenol
CC(=O)Nc1ccc(C)c(OCCOc2ccccc2)c1
18a
CC(=O)Nc1ccc(C)c(OCCOc2ccccc2)c1
N-[4-methyl-3-(2-phenoxy-ethoxy)-phenyl]-acetamide
COc1ccc(NC(C)=O)cc1OCCOc1ccccc1
compound 19a
Rendement 62.0%
COc1ccc(NC(C)=O)cc1OCCOc1ccccc1
N-[4-methoxy-3-(2-phenoxy-ethoxy)-phenyl]-acetamide
Rendement 62.0%

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Mode opératoire

The compound 19a was prepared starting from 5-amino-2-methoxy phenol (800 mg, 5.75 mmol) according to the procedure described for the synthesis of 18a (as in Example 27) in 62% yield as white powder.

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US08877752B2uspto-grants-2014_11