Réaction #417964

Équation de réaction

Acetic anhydride

4-chloro-3-hydroxy aniline

→

product 17a

Rendement 93.0%

N-(4-chloro-3-hydroxyphenyl)acetamide

Rendement 93.0%

Solvants

acetic acid

Conditions de réaction

Traitement

1. 1
   Températurethe reaction was refluxed for 5 mins
2. 2
   FiltrationIt was filtered off
3. 3
   Lavagewashed with water (10 mL)
4. 4
   Autredried

Mode opératoire

Acetic anhydride (3.0 mL, 42.0 mmol) was added to a solution of 4-chloro-3-hydroxy aniline (4.0 g, 28 mmol) in acetic acid (20 mL), and the reaction was refluxed for 5 mins. The reaction mixture was cooled to room temperature and the product was solidified. It was filtered off and washed with water (10 mL) and dried to obtain the product 17a in 93% yield (4.8 g) as a creamy white solid. There was no need for further purification.

Source