Réaction #417951

Équation de réaction

4-bromo-5-fluoro-pyridin-2-ol

ethyliodide

→

4-Bromo-2-ethoxy-5-fluoro-pyridine

Solvants

DCM

Conditions de réaction

Traitement

1. 1
   AutreThe reaction is quenched by the addition of water
2. 2
   workup.ADDITIONDCM is added
3. 3
   Filtrationthe resulting mixture is filtered
4. 4
   Séchagedried over MgSO4
5. 5
   Filtrationfiltered again
6. 6
   Autrethe solvent is removed in vacuo

Mode opératoire

0.20 g (1.04 mmol) 4-bromo-5-fluoro-pyridin-2-ol, 0.83 mL (10.4 mmol) ethyliodide and 0.43 g (1.56 mmol) Ag2CO3 are added to 5 mL DCM and stirred at r.t. over night. The reaction is quenched by the addition of water. DCM is added, the resulting mixture is filtered and the organic layer is separted, dried over MgSO4, filtered again and the solvent is removed in vacuo.

Source