Réaction #417949

Équation de réaction

5-bromo-2-fluoropyridine

cyclopropane methanol

NaH

→

5-Bromo-2-cyclopropylmethoxy-pyridine

Solvants

THF

Conditions de réaction

Traitement

1. 1
   workup.STIRRINGthe mixture is stirred at r.t. over night
2. 2
   AutreThe reaction is quenched by the addition of water
3. 3
   Extractionextracted with EtOAc
4. 4
   Séchagedried over MgSO4
5. 5
   Filtrationfiltered
6. 6
   Autrethe solvent is removed in vacuo
7. 7
   AutreThe crude product is purified by HPLC (MeOH/H2O/FA)

Mode opératoire

0.49 g (6.82 mmol) cyclopropane methanol in 10 mL THF are charged with 0.42 g (11.4 mmol) NaH and the reaction mixture is stirred at r.t. for 20 min. Then 1.00 g (5.68 mmol) 5-bromo-2-fluoropyridine are added and the mixture is stirred at r.t. over night. The reaction is quenched by the addition of water and extracted with EtOAc. The organic layers are combined, dried over MgSO4, filtered and the solvent is removed in vacuo. The crude product is purified by HPLC (MeOH/H2O/FA).

Source