Réaction #417948

Équation de réaction

2-bromo-5-hydroxypyridine

1-bromopropane

K2CO3

→

2-Bromo-5-propoxy-pyridine

Solvants

ACN

Conditions de réaction

Traitement

1. 1
   Températureat reflux over night
2. 2
   AutreAfterwards the reaction is quenched by the addition of water
3. 3
   Extractionextracted with TBME
4. 4
   Séchagedried over MgSO4
5. 5
   Filtrationfiltered
6. 6
   Autrethe solvent is removed in vacuo
7. 7
   AutreThe crude product is purified by column chromatography (silica gel, PE/EtOAc)

Mode opératoire

10.0 g (57.5 mmol) 2-bromo-5-hydroxypyridine, 28.3 g (230 mmol) 1-bromopropane and 19.9 g (143.7 mmol) K2CO3 are added to 1 L ACN and stirred at reflux over night. Afterwards the reaction is quenched by the addition of water and extracted with TBME. The org. layers are combined, dried over MgSO4, filtered and the solvent is removed in vacuo. The crude product is purified by column chromatography (silica gel, PE/EtOAc).

Source