Réaction #417946

Équation de réaction

2-bromo-2-fluoropyridine

(2,2-difluoro-ethyl)-methyl-amine hydrochloride

DIPEA

→

6-Bromo-N-(2,2-difluoroethyl)-N-methylpyridin-2-amine

Conditions de réaction

Traitement

1. 1
   AutreThe reaction is quenched by the addition of water
2. 2
   Extractionextracted with DCM
3. 3
   Séchagelayers are dried over MgSO4
4. 4
   Filtrationfiltered

Mode opératoire

88.0 mg (0.50 mmol) 2-bromo-2-fluoropyridine, 78.9 mg (0.60 mmol) (2,2-difluoro-ethyl)-methyl-amine hydrochloride and 0.17 mL (1.00 mmol) DIPEA are stirred at 90° C. over night. The reaction is quenched by the addition of water and extracted with DCM. The combined org. layers are dried over MgSO4, filtered and the solvent is removend in vacuo.

Source