Réaction #417943

ord-10572e9e42914c269065c8e47baaf881

Équation de réaction

C[C@H](N)c1ccc(Br)cc1
(S)-1-(4-bromophenyl)ethylamine
CC(=O)OC(C)=O
acetic anhydride
→
CC(=O)N[C@@H](C)c1ccc(Br)cc1
(S)—N-(1-(4-Bromophenyl)ethyl)acetamide

Réactifs

C[C@H](N)c1ccc(Br)cc1
(S)-1-(4-bromophenyl)ethylamine
CC(=O)OC(C)=O
acetic anhydride

Réactifs

Aucun

Solvants

ClCCl
DCM

Conditions de réaction

Température
25°CELSIUS
Conditions détaillées
See reaction.notes.procedure_details.

Traitement

  1. 1
    AutreThen the cooling is removed
  2. 2
    LavageAfterwards the mixture is consecutively washed with water, sat. aq. NaHCO3 solution, water, diluted aq. citric acid solution and again water
  3. 3
    Séchagelayer is dried over MgSO4
  4. 4
    Filtrationfiltered
  5. 5
    Autrethe solvent is removed in vacuo

Mode opératoire

To 200 g (1.00 mol) (S)-1-(4-bromophenyl)ethylamine in 800 mL DCM are slowly added 94.5 mL (1.00 mol) acetic anhydride while cooling the mixture to 20-30° C. Then the cooling is removed and the reaction mixture is stirred at r.t. over night. Afterwards the mixture is consecutively washed with water, sat. aq. NaHCO3 solution, water, diluted aq. citric acid solution and again water. The org. layer is dried over MgSO4, filtered and the solvent is removed in vacuo.

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US08877741B2uspto-grants-2014_11