Réaction #41528

Équation de réaction

carbon disulfide

potassium hydroxide

ethanol

3-(4-fluoro-phenoxy)-5-(pyridin-3-yloxy)-benzene-1,2-diamine

4-(4-Fluoro-phenoxy)-2-pyridin-2-yl-6-(pyridin-3-yloxy)-1H-benzimidazole

→

4-(4-fluoro-phenoxy)-6-(pyridin-3-yloxy)-1H-benzimidazole-2-thiol

Solvants

ethyl acetate

Conditions de réaction

Traitement

1. 1
   Autrethe reaction liquid
2. 2
   AutreThe reaction liquid
3. 3
   Lavagewashed with water and saturated saline in order
4. 4
   Séchagedried with anhydrous magnesium sulfate
5. 5
   AutreThe solvent was evaporated away under reduced pressure
6. 6
   Autreto obtain the entitled compound

Mode opératoire

0.06 ml of carbon disulfide and 54 mg of potassium hydroxide were added to an ethanol (2.0 ml) solution of 273 mg of 3-(4-fluoro-phenoxy)-5-(pyridin-3-yloxy)-benzene-1,2-diamine obtained in Example 68, and the reaction liquid was stirred overnight at 80° C. The reaction liquid was diluted with ethyl acetate, washed with water and saturated saline in order, and dried with anhydrous magnesium sulfate. The solvent was evaporated away under reduced pressure to obtain the entitled compound.

Source