Réaction #41460

Équation de réaction

HCl

3-hydrazinylbenzoic acid

2-fluoro-5-iodobenzaldehyde

caesium carbonate

→

title compound

Rendement 98.0%

3-(2-(2-fluoro-5-iodobenzylidene)hydrazinyl)benzoic acid

Rendement 98.0%

Solvants

Water

DMF

Conditions de réaction

Traitement

1. 1
   AutreThe beige-orange precipitate that formed
2. 2
   Autrewas collected by,
3. 3
   Filtrationfiltration
4. 4
   Lavagewashed with water
5. 5
   Autredried in vacuo

Mode opératoire

3-hydrazinylbenzoic acid (1.52 g, 10 mmol)), 2-fluoro-5-iodobenzaldehyde (2.5 g, 10 mmol) and caesium carbonate (3.26 g, 10 mmol) were stirred in DMF (10 mL) at r.t. under argon atmosphere for 2.5 h. Water (40 mL) was added and the clear solution was acidified with aqueous HCl (1.7 M). The beige-orange precipitate that formed was collected by, filtration, washed with water and dried in vacuo to give the title compound (3.75 g, 98%).

Source