Réaction #41456

Équation de réaction

HCl

4-hydrazinylbenzoic acid

2-fluoro-5-iodobenzaldehyde

caesium carbonate

→

4-(2-(2-fluoro-5-iodobenzylidene)hydrazinyl)benzoic acid

Rendement 98.1%

Solvants

Water

DMF

Conditions de réaction

Traitement

1. 1
   AutreThe light yellow precipitate that formed
2. 2
   Filtrationwas collected by filtration
3. 3
   Lavagewashed with water
4. 4
   Autredried in vacuo

Mode opératoire

4-hydrazinylbenzoic acid (1.54 g, 10 mmol), 2-fluoro-5-iodobenzaldehyde (2.52 g, 10 mmol) and caesium carbonate (3.27 g, 10 mmol) was stirred in DMF (10 mL) at r.t. for 70 min. Water (40 mL) was then added and the clear solution was acidified with aqueous HCl (1.7 M). The light yellow precipitate that formed was collected by filtration, washed with water and dried in vacuo to give 4-(2-(2-fluoro-5-iodobenzylidene)hydrazinyl)benzoic acid (3.77 g, 98%)

Source