Réaction #41379

Équation de réaction

(1R,2S)-1-(1-(4-fluorophenyl)-1H-indazol-5-yloxy)-1-phenylpentan-2-amine

triethyl amine

2-chloro-2-oxoethyl acetate

→

N-((1R,2S)-1-(1-(4-fluorophenyl)-1H-indazol-5-yloxy)-1-phenylpentan-2-yl)-2-hydroxyacetamide

Solvants

THF

Conditions de réaction

Traitement

1. 1
   AutreThe solvent was removed under reduced pressure
2. 2
   workup.ADDITIONTo the crude solid was added Methanol (300 μl) and ammonium hydroxide (100 μl, 28%)
3. 3
   workup.STIRRINGThe solution was stirred over night

Mode opératoire

To a stirred solution of (1R,2S)-1-(1-(4-fluorophenyl)-1H-indazol-5-yloxy)-1-phenylpentan-2-amine (91a, 13 mg, 0.03 mmol) in dry THF (1 ml) were added, at r.t., triethyl amine (28 μl, 0.2 mmol) and 2-chloro-2-oxoethyl acetate (10.8 μl, 0.1 mmol). The reaction was stirred over night. The solvent was removed under reduced pressure. To the crude solid was added Methanol (300 μl) and ammonium hydroxide (100 μl, 28%). The solution was stirred over night.

Source