Réaction #41364

Équation de réaction

N,N-Diisopropylamine

(1R,2S)-1-(1-(4-fluorophenyl)indazol-5-yloxy)-1-(3-methoxyphenyl)propan-2-amine

2-amino-2-oxoacetic acid

HBTU

→

title compound

Rendement 69.0%

N-[(1R,2S)-1-[1-(4-Fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]oxamide

Rendement 69.0%

Solvants

dichloromethane

Conditions de réaction

Traitement

1. 1
   ConcentrationThe clear solution was concentrated
2. 2
   Autrepurified by HPLC

Mode opératoire

N,N-Diisopropylamine (0.049 mL, 0.30 mmol) was added to a suspension of (1R,2S)-1-(1-(4-fluorophenyl)indazol-5-yloxy)-1-(3-methoxyphenyl)propan-2-amine (53 mg, 0.14 mmol), 2-amino-2-oxoacetic acid (12 mg, 0.14 mmol) and HBTU (62 mg, 0.16 mmoL) in dichloromethane (2 mL). The mixture was stirred at r.t. overnight. The clear solution was concentrated and purified by HPLC to give the title compound (43 mg, 69%).

Source