Réaction #41263

Équation de réaction

2-{4′-[(3aR,6aR)-5-Methylhexahydropyrrolo[3,4-b]pyrrol-1(2H)-yl]-1,1′-biphenyl-4-yl}pyridazin-3(2H)-one tartrate

dichloromethane

→

2-{4′-[(3aR,6aR)-5-Methylhexahydropyrrolo[3,4-b]pyrrol-1(2H)-yl]-1,1′-biphenyl-4-yl}pyridazin-3(2H)-one L-tartrate salt monohydrate

Solvants

water

—

solution

Conditions de réaction

Traitement

1. 1
   Autrewas prepared
2. 2
   Températuremaintained for 1.5 hrs
3. 3
   TempératureIt was further heated to about 70° C
4. 4
   FiltrationThe suspension was then filtered
5. 5
   Températurethe supernatant cooled to ambient temperatures naturally in the water bath

Mode opératoire

2-{4′-[(3aR,6aR)-5-Methylhexahydropyrrolo[3,4-b]pyrrol-1(2H)-yl]-1,1′-biphenyl-4-yl}pyridazin-3(2H)-one tartrate (Form A) was suspended in 1 mL of solution mixture, which was prepared by mixing 3.0 mL of dichloromethane with 1.5 mL of 20% water (in methanol). The suspension was vortexed and heated in a shaking water bath to about 40° C. and maintained for 1.5 hrs. It was further heated to about 70° C. The suspension was then filtered. The water bath was turned off, and the supernatant cooled to ambient temperatures naturally in the water bath. Single crystals were offered.

Source