Réaction #41157

Équation de réaction

t-Butyl nitrite

5-amino-1-cyclohexyl-1H-pyrazole-4-carboxylic acid ethyl ester

HCl

→

5-chloro-1-cyclohexyl-1H-pyrazole-4-carboxylic acid ethyl ester

Rendement 42.0%

Solvants

acetonitrile

acetonitrile

Conditions de réaction

Traitement

1. 1
   workup.WAITat 70° C. for 1.25 hour
2. 2
   TempératureThe mixture was cooled to room temperature
3. 3
   Extractionextracted with methylene chloride
4. 4
   LavageThe organic phase was washed sequentially with water and brine
5. 5
   ExtractionThe aqueous phases were back extracted with a second portion of methylene chloride
6. 6
   Séchagedried over sodium sulfate
7. 7
   Concentrationconcentrated in vacuo
8. 8
   AutreThe crude residue was chromatographed by flash chromatography
9. 9
   Lavageeluting with a gradient of 10-50% ethyl acetate/hexanes

Mode opératoire

Copper(I) chloride (2.500 g, 25.25 mmol) was suspended in 7.0 mL cold (ice/acetone bath) anhydrous acetonitrile. t-Butyl nitrite (5.75 mL, 90%, 43.56 mmol) was added, followed by a suspension of 5-amino-1-cyclohexyl-1H-pyrazole-4-carboxylic acid ethyl ester (4.408 g, 18.58 mmol) in 27.0 mL acetonitrile. The mixture was stirred at room temperature for 45 minutes and then at 70° C. for 1.25 hour. The mixture was cooled to room temperature, slowly added to 6N HCl (17.5 mL) and then extracted with methylene chloride. The organic phase was washed sequentially with water and brine. The aqueous phases were back extracted with a second portion of methylene chloride. The two organic phases were combined, dried over sodium sulfate and concentrated in vacuo. The crude residue was chromatographed by flash chromatography eluting with a gradient of 10-50% ethyl acetate/hexanes to give 5-chloro-1-cyclohexyl-1H-pyrazole-4-carboxylic acid ethyl ester (1.98 g; 42%). Mass spectrum: m/z: 257.3 (M+H).

Source