Réaction #40951

Équation de réaction

Water

3-Benzoyl-5-iodo-1H-pyrimidine-2,4-dione

K2CO3

bromo-chloro-propane

→

title compound

Rendement 98.1%

3-Benzoyl-1-(3-chloro-propyl)-5-iodo-1H-pyrimidine-2,4-dione

Rendement 98.1%

Solvants

DMF

Conditions de réaction

Traitement

1. 1
   workup.STIRRINGthe mixture stirred at room temperature overnight
2. 2
   Extractionthe mixture was extracted with ethyl acetate
3. 3
   SéchageThe organic phase was dried (Na2SO4)
4. 4
   Filtrationfiltered
5. 5
   Autreevaporated

Mode opératoire

3-Benzoyl-5-iodo-1H-pyrimidine-2,4-dione (Prep36, 3 g, 8.77 mmol) and K2CO3 (1.2 g, 8.77 mmol) were suspended in dry DMF (45 mL) and stirred at room temperature for 1 h. Then, bromo-chloro-propane (2.7 mL, 17.5 mmol) was added dropwise and the mixture stirred at room temperature overnight. Water was added and the mixture was extracted with ethyl acetate. The organic phase was dried (Na2SO4), filtered and evaporated to give the title compound as a pale yellow oil (3.6 g, 98% yield).

Source