Réaction #40917

Équation de réaction

diethyl ether

4-oxo-cyclohexanecarboxylic acid ethyl ester

ethylene glycol

p-toluenesulfonic acid

→

1,4-dioxa-spiro[4.5]decane-8-carboxylic acid ethyl ester

Solvants

toluene

Conditions de réaction

Traitement

1. 1
   Lavagewashed with water, sodium hydrogen carbonate solution and sodium chloride solution
2. 2
   SéchageThe solution was dried (Na2SO4)
3. 3
   Concentrationconcentrated by evaporation in vacuo
4. 4
   Autrethe remaining colorless liquid was processed further without purification

Mode opératoire

4-oxo-cyclohexanecarboxylic acid ethyl ester (52.8 g, 0.31 mole, Merck, Order No. 814249), ethylene glycol (67.4 g, 1.08 mole) and p-toluenesulfonic acid (0.7 g) in toluene (160 ml) were stirred for 20 hours at RT, and the reaction solution was poured into diethyl ether (300 ml) and washed with water, sodium hydrogen carbonate solution and sodium chloride solution. The solution was dried (Na2SO4), concentrated by evaporation in vacuo, and the remaining colorless liquid was processed further without purification.

Source