Réaction #4070

Équation de réaction

methyl bromo-phenylacetate

methyl ammonium chloride

sodium bicarbonate

water

→

title compound

Rendement 71.2%

Methyl Methyamino-phenylacetate

Rendement 71.2%

Solvants

methylene chloride

Conditions de réaction

Traitement

1. 1
   Températureto refluxed
2. 2
   Températurerefluxed for about 18 hours
3. 3
   TempératureThe mixture was then cooled
4. 4
   Lavagewashed three times with water
5. 5
   Séchagedried over magnesium sulfate
6. 6
   Concentrationconcentrated by vacuum evaporation

Mode opératoire

In this example a mixture containing 30.7 g of methyl bromo-phenylacetate, 36.2 g of methyl ammonium chloride (i.e. CH3NH3Cl); 3.0 g of benzyltriethylammonium chloride and 67.5 g of sodium bicarbonate in about 300 ml of methylene chloride (and about 25 ml of water) was warmed to refluxed and refluxed for about 18 hours. The mixture was then cooled and washed three times with water, dried over magnesium sulfate and concentrated by vacuum evaporation affording 17.1 g of the title compound as an oil.

Source