Réaction #40394

Équation de réaction

3,4-difluorobenzyl bromide

acetone

→

1-(3,4-difluorophenyl)-2-methylpropan-2-ol

Conditions de réaction

Mode opératoire

From 23.0 g (111 mmol) of 3,4-difluorobenzyl bromide a Grignard is prepared, which is then reacted with 11.6 mL (158 mmol) of acetone. Slightly yellow oil. Yield: 9.7 g (47%); Rf value: 0.55 (ethyl acetate-petroleum ether (1:3)).

Source