Réaction #40340

Équation de réaction

caustic soda

1-bromohexane

N-(4,5,6,7-tetrahydro-thiazolo[5,4-c]pyridine-2-yl)-guanidine

caesium carbonate

→

title compound

N-(5-hexyl-4,5,6,7-tetrahydro-thiazolo[5,4-c]pyridine-2-yl)-guanidine

Solvants

dimethylformamide

Conditions de réaction

Traitement

1. 1
   Extractionis extracted with ethyl acetate
2. 2
   Séchagethe combined organic phases are dried over sodium sulphate
3. 3
   Concentrationconcentrated by evaporation

Mode opératoire

1-bromohexane (0.11 mmol) is added to a suspension of N-(4,5,6,7-tetrahydro-thiazolo[5,4-c]pyridine-2-yl)-guanidine (0.1 mmol) and caesium carbonate (0.22 mmol) in dimethylformamide (0.3 ml) and the reaction mixture is stirred overnight at room temperature. After adding 2M caustic soda solution (1 ml) the mixture is extracted with ethyl acetate, the combined organic phases are dried over sodium sulphate and then concentrated by evaporation, the title compound being obtained in pure form.

Source