Réaction #4027

Équation de réaction

2-(p-methoxyphenyl)-5-octylpyridine

hydrobromic acid

water

→

2-(p-hydroxyphenyl)-5-octylpyridine

Solvants

acetic acid

Conditions de réaction

Traitement

1. 1
   Températurethe solution was heated for 15 hours
2. 2
   Températureunder reflux
3. 3
   Extractionthe organic layer was extracted with chloroform
4. 4
   LavageAfter washing the
5. 5
   Extractionextract three times with water
6. 6
   Autrethe chloroform was removed by distillation
7. 7
   AutreThe residue was recrystallized from a mixture of acetone and hexane

Mode opératoire

The 2-(p-methoxyphenyl)-5-octylpyridine was dissolved in 100 ml of acetic acid. 8 ml of 48% hydrobromic acid was added to the reaction solution and the solution was heated for 15 hours under reflux. 100 ml of water was added to the reaction solution and the organic layer was extracted with chloroform. After washing the extract three times with water, the chloroform was removed by distillation. The residue was recrystallized from a mixture of acetone and hexane to yield 8.3 g (0.029 mol) of 2-(p-hydroxyphenyl)-5-octylpyridine.

Source