Réaction #4009

Équation de réaction

2-amino-4-chloro-6-chloromethylpyrimidine

potassium t-butoxide

n-butanol

→

2-amino-4-n-butoxy-6-chloromethylpyrmidine

Conditions de réaction

Traitement

1. 1
   TempératureAfter this time, the solution was cooled
2. 2
   Autreevaporated in vacuo
3. 3
   AutreThe residue was partitioned between ethyl acetate and water
4. 4
   Autrethe organic phase was separated
5. 5
   Lavagewashed three times with water
6. 6
   Séchagethen dried (MgSO4)
7. 7
   AutreEvaporation of the solvent
8. 8
   Autregave the crude product which
9. 9
   Autrewas purified by chromatography on silica (Merck Kieselgel 60)
10. 10
    Lavageeluted with ether

Mode opératoire

3,56 Parts of 2-amino-4-chloro-6-chloromethylpyrimidine and 2.24 parts of potassium t-butoxide were dissolved in 60 parts of n-butanol at room temperature then the solution was heated at 50° C. for 2 hours, with stirring. After this time, the solution was cooled and evaporated in vacuo. The residue was partitioned between ethyl acetate and water and the organic phase was separated and washed three times with water then dried (MgSO4). Evaporation of the solvent gave the crude product which was purified by chromatography on silica (Merck Kieselgel 60) eluted with ether to give 2-amino-4-n-butoxy-6-chloromethylpyrmidine as an oil.

Source