Réaction #3985

Équation de réaction

4-Amino-1-(naphth-2-ylmethyl)piperidine

benzoylisothiocyanate

→

1-Benzoyl-3-[1-(naphth-2-ylmethyl)piperid-4-yl]thiourea

Solvants

toluene

Conditions de réaction

Traitement

1. 1
   AutreThe solvent was evaporated
2. 2
   workup.DISSOLUTIONthe gum dissolved in isopropyl alcohol
3. 3
   AutreThe solvent was evaporated
4. 4
   workup.DISSOLUTIONthe residue dissolved in ethyl acetate
5. 5
   AutreThe title compound crystallised
6. 6
   Filtrationwas filtered
7. 7
   Séchagedried as the monohydrochloride quarterhydrate salt, m.p. 212°-214° C.

Mode opératoire

4-Amino-1-(naphth-2-ylmethyl)piperidine (1.0 g, 0.0042 m) and benzoylisothiocyanate (0.69 g, 0.0042 m) in toluene (120 cm3) was stirred at room temperature for 6 hours. The solvent was evaporated and the gum dissolved in isopropyl alcohol and acidified with ethanolic HCl. The solvent was evaporated and the residue dissolved in ethyl acetate. The title compound crystallised and was filtered and dried as the monohydrochloride quarterhydrate salt, m.p. 212°-214° C.

Source