Réaction #3923

Équation de réaction

3-(4-chlorophenyl)propyl piperazine

potassium hydroxide

1-bromo-3-chloropropane

→

1-[3-(4-chlorophenyl)propyl]-4-(3-chloropropyl)piperazine dihydrochloride

Rendement 104.9%

Solvants

dimethyl sulfoxide

Conditions de réaction

Mode opératoire

The procedure described in Example 17(a) was followed, using 27.0 g of 3-(4-chlorophenyl)propyl piperazine, 22.0 g of potassium hydroxide, 250 ml of dimethyl sulfoxide and 17.7 g of 1-bromo-3-chloropropane to give 22.9 g (54% of theory) of 1-[3-(4-chlorophenyl)propyl]-4-(3-chloropropyl)piperazine dihydrochloride.

Source