Réaction #3921

Équation de réaction

thiourea

sodium hydroxide

triethylamine

1-(3-phenylpropyl)-4-(3-chloropropyl)piperazine dihydrochloride

→

3-[4-(3-phenylpropyl)piperazin-1-yl]propanethiol dihydrochloride

Rendement 82.0%

Solvants

water

ethanol

Conditions de réaction

Mode opératoire

The procedure described in Example 1(b) was followed, using 19.0 g of thiourea, 44.0 g of 1-(3-phenylpropyl)-4-(3-chloropropyl)piperazine dihydrochloride, 25 g of triethylamine and 250 ml of reagent ethanol. The hydrolysis was effected with 10.0 g of sodium hydroxide in 50 ml of water. Work-up, as described above, gave 35.8 g (82% of theory) of 3-[4-(3-phenylpropyl)piperazin-1-yl]propanethiol dihydrochloride as a white crystalline solid, M.p. 237°-239° C.

Source