Réaction #3915

Équation de réaction

thiourea

sodium hydroxide

triethylamine

1-(4-chlorophenethyl)-4-(3-chloropropyl)piperazine dihydrochloride

→

3-[4-(4-chlorophenethyl)piperazin-1-yl]propanethiol dihydrochloride

Rendement 176.1%

Solvants

water

ethanol

Conditions de réaction

Mode opératoire

The procedure described in Example 1(b) was followed, using 1.3 g of thiourea, 6.4 g of 1-(4-chlorophenethyl)-4-(3-chloropropyl)piperazine dihydrochloride, 1.6 g of triethylamine and 150 ml of reagent ethanol. The hydrolysis was effected with 3.5 g of sodium hydroxide and 40 ml of water. Work-up, as described above, gave 5.6 g (89% of theory) of 3-[4-(4-chlorophenethyl)piperazin-1-yl]propanethiol dihydrochloride as a white crystalline solid, M.p. 279°-281° C.

Source