Réaction #3902

Équation de réaction

4-ethoxycarbonylphenyl isocyanate

3-[4-(4-chlorobenzyl)piperazin-1-yl]propanethiol dihydrochloride

triethylamine

→

N-(4-ethoxycarbonylphenyl)-S-{3-[4-(4-chlorobenzyl)piperazin-1-yl]propyl}thiocarbamate dihydrochloride

Rendement 55.2%

Solvants

methylene chloride

Conditions de réaction

Mode opératoire

The procedure described in Example 2 was followed, using 1.1 g of 4-ethoxycarbonylphenyl isocyanate, 2.0 g of 3-[4-(4-chlorobenzyl)piperazin-1-yl]propanethiol dihydrochloride, 0.7 g of triethylamine and 50 ml of methylene chloride, to give 0.85 g (28% of theory) of N-(4-ethoxycarbonylphenyl)-S-{3-[4-(4-chlorobenzyl)piperazin-1-yl]propyl}thiocarbamate dihydrochloride as a white crystalline solid, M.p. 231°-233° C.

Source