Réaction #3887

Équation de réaction

phenyl isocyanate

3-(4-benzylpiperazin-1-yl)propanethiol dihydrochloride

triethylamine

→

N-phenyl-S-[3-(4-benzylpiperazin-1-yl)propyl]thiocarbamate dihydrochloride monohydrate

Rendement 41.9%

Solvants

methylene chloride

Conditions de réaction

Traitement

1. 1
   TempératureThe mixture was refluxed for four hours
2. 2
   Lavagewashed with water
3. 3
   Séchagedried (sodium sulfate)
4. 4
   AutrePrecipitation of the salt with ethereal hydrochloric acid

Mode opératoire

1.6 g of phenyl isocyanate were added to a solution of 4.0 g of 3-(4-benzylpiperazin-1-yl)propanethiol dihydrochloride and 2.6 g of triethylamine in 50 ml of methylene chloride. The mixture was refluxed for four hours, washed with water and dried (sodium sulfate). Precipitation of the salt with ethereal hydrochloric acid gave 1.2 g (20% of theory) of N-phenyl-S-[3-(4-benzylpiperazin-1-yl)propyl]thiocarbamate dihydrochloride monohydrate as a white crystalline solid, M.p. 216°-219° C.

Source