Réaction #379

Équation de réaction

COC(=O)c1ccc(I)cc1O

CC(C)(C)OC(=O)N1CCNC

→

COC(=O)c1ccc(N2CCN(C

Solvants

COCCOC

Conditions de réaction

Mode opératoire

tert-butyl piperazine-1-carboxylate (0.670 g, 3.60 mmol) and methyl 2-hydroxy-4-iodobenzoate (1 g, 3.60 mmol), BINAP (0.224 g, 0.36 mmol), cesium carbonate (2.461 g, 7.55 mmol) were put inDME (18 mL), tris(dibenzylideneacetone)dipalladium(0) (0.165 g, 0.18 mmol) was added last. Reaction wsa purged by nitrogen, and heated at90 °C overnight. No desired product was found.

Source