Réaction #3763

Équation de réaction

isobutyryl chloride

p-iodoaniline

pyridine

water

Isobutyryl chloride

→

N-(4-iodophenyl)isobutyramide

Rendement 97.4%

Solvants

acetonitrile

Conditions de réaction

Traitement

1. 1
   FiltrationPrecipitated crystalline solids were collected by filtration

Mode opératoire

To a dispersion of p-iodoaniline (219.0 g, 1 mol) in acetonitrile(1000 ml) was added pyridine (81.0 ml, 1 mol). Isobutyryl chloride (100.5 ml, 1 mol) was added dropwise to the mixture over 1 hour in an ice bath. The mixture was further stirred for one hour following the addition of isobutyryl chloride and to the mixture was added water (3000 ml). Precipitated crystalline solids were collected by filtration to give N-(4-iodophenyl)isobutyramide (281.7 g, Yield: 97%).

Source