Réaction #3723

ord-f7b8b5a24c1b45c195681022ace26b53

Équation de réaction

Cc1cn([C@H]2C[C@H](N=[N+]=[N-])[C@@H](CO)O2)c(=O)[nH]c1=O
3'-deoxy-3'-azidothymidine
O=c1[nH]c(=O)n([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)cc1F
5-fluorouridine
OC[C@H]1O[C@@H](n2cnc3c(=S)nc[nH]c32)[C@H](O)[C@@H]1O
6-mercaptopurine-9-β-D-ribofuranoside
Nc1nc2c(ncn2COCCCO)c(=O)[nH]1
9-{[(1-hydroxymethyl)ethoxy]-methyl}guanine
CCOCn1cnc2c(=O)[nH]c(N)nc21
9- (ethoxymethyl)guanine
Cc1cn([C@H]2C[C@H](F)[C@@H](CO)O2)c(=O)[nH]c1=O
3'-deoxy-3'-fluorothymidine
→
Nc1nc(O)c2ncn(COC(CO)CO)c2n1
ganciclovir

Réactifs

Cc1cn([C@H]2C[C@H](N=[N+]=[N-])[C@@H](CO)O2)c(=O)[nH]c1=O
3'-deoxy-3'-azidothymidine
—
6-methylmercaptopurine-9-β-D-ribofuranoside
O=c1[nH]c(=O)n([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)cc1F
5-fluorouridine
OC[C@H]1O[C@@H](n2cnc3c(=S)nc[nH]c32)[C@H](O)[C@@H]1O
6-mercaptopurine-9-β-D-ribofuranoside
Nc1nc2c(ncn2COCCCO)c(=O)[nH]1
9-{[(1-hydroxymethyl)ethoxy]-methyl}guanine
CCOCn1cnc2c(=O)[nH]c(N)nc21
9- (ethoxymethyl)guanine
Cc1cn([C@H]2C[C@H](F)[C@@H](CO)O2)c(=O)[nH]c1=O
3'-deoxy-3'-fluorothymidine

Réactifs

Aucun

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Mode opératoire

3'-deoxy-3'-azidothymidine, 3'-deoxy-3'-fluorothymidine, 5-fluorouridine, 6-mercaptopurine-9-β-D-ribofuranoside, 6-methylmercaptopurine-9-β-D-ribofuranoside, 9-{[(1-hydroxymethyl)ethoxy]-methyl}guanine and 9- (ethoxymethyl)guanine.

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US05734042uspto-grants-1998_03