Réaction #3708

Équation de réaction

3-methoxy-4-nitrobenzoic acid

thionyl chloride

→

3-Methoxy-4-nitrobenzoyl chloride

Solvants

iso-octane

Conditions de réaction

Traitement

1. 1
   Températureis heated
2. 2
   Températureto reflux for 2 hours
3. 3
   Autrethe mixture evaporated in vacuo to a solid residue
4. 4
   LavageThe residue is washed with iso-octane (2×2 ml)
5. 5
   Autredried in vacuo
6. 6
   Autreto give 1.08 g of cream

Mode opératoire

A stirred suspension of 1.0 g of 3-methoxy-4-nitrobenzoic acid and 1.40 ml of thionyl chloride is heated to reflux for 2 hours. The mixture is cooled to room temperature, 2 ml of iso-octane added and the mixture evaporated in vacuo to a solid residue. The residue is washed with iso-octane (2×2 ml), dried in vacuo to give 1.08 g of cream colored solid.

Source