Réaction #367666

Équation de réaction

6-methoxynaphthoic acid

potassium carbonate

dimethyl sulfate

→

methyl 6-methoxynaphthoate

Rendement 90.9%

Solvants

acetone

acetone

Conditions de réaction

Traitement

1. 1
   Températurewas heated to 50°-55° C. for 15 minutes
2. 2
   Autrewere then slowly dripped in over a period of 15 minutes
3. 3
   TempératureThe mixture was then heated
4. 4
   Températureat reflux for one hour

Mode opératoire

A mixture of 9.1 g of 6-methoxynaphthoic acid and 7.2 g of anhydrous potassium carbonate in 45 ml of acetone was heated to 50°-55° C. for 15 minutes, and 4.5 ml of dimethyl sulfate were then slowly dripped in over a period of 15 minutes. The mixture was then heated at reflux for one hour and cooled to room temperature, after which all the acetone was stripped under vacuum. After workup, it was determined that the process resulted in the formation of 8.85 g of methyl 6-methoxynaphthoate having an HPLC purity of 83.3%.

Source