Réaction #367052

Équation de réaction

N-benzyloxycarbonyl-7-chloro-7-cyano-2-azabicyclo[2.2.2]oct-5-ene

acetic acid hydrogen bromide

→

7-Chloro-7-cyano-2-azabicyclo[2.2.2]oct-5-ene hydrogen bromide

Solvants

acetic acid

Conditions de réaction

Traitement

1. 1
   Autreis then evaporated
2. 2
   AutreThe evaporation residue is crystallized from acetone

Mode opératoire

5.0 g. (0.0165 moles) of N-benzyloxycarbonyl-7-chloro-7-cyano-2-azabicyclo[2.2.2]oct-5-ene are dissolved in a mixture of 30 ml. of glacial acetic acid and 15 ml. of a 4-5N glacial acetic acid/hydrogen bromide mixture. The reaction mixture is allowed to stand at room temperature for 10 minutes, and is then evaporated. The evaporation residue is crystallized from acetone.

Source