Réaction #3655

Équation de réaction

4-nitrobenzoyl chloride

5,6-dihydro-4H-[1,2,4]-triazolo[4,3-a][1,5]benzodiazepine

triethylamine

→

desired product

5,6-Dihydro-6-(4-nitrobenzoyl)-4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepine

Solvants

dichloromethane

dichloromethane

Conditions de réaction

Traitement

1. 1
   Lavagewashed with water, aqueous NaHCO3 and brine
2. 2
   SéchageThe organic layer is dried (Na2SO4)
3. 3
   Autrethe solvent removed under vacuum
4. 4
   AutreThe residue is purified by chromatography on silica gel

Mode opératoire

To a mixture of 3 mmol of 5,6-dihydro-4H-[1,2,4]-triazolo[4,3-a][1,5]benzodiazepine in 10 ml of dichloromethane under argon is added 5 mmol of triethylamine. To the mixture is added dropwise 3.3 mmol of 4-nitrobenzoyl chloride in 3 ml of dichloromethane. The mixture is stirred at room temperature 3 hours and then washed with water, aqueous NaHCO3 and brine. The organic layer is dried (Na2SO4) and the solvent removed under vacuum. The residue is purified by chromatography on silica gel to give the desired product as a solid.

Source