Réaction #360879

ord-f0380915aefc42ce8859461679dce404

Équation de réaction

C[C@]12CC[C@H]3[C@@H]([C@@H](O)C=C4C[C@@H](O)CC[C@@]43C)[C@@H]1C[C@@H](Br)[C@@H]2O
16α-bromo-3β,7β,17β-trihydroxyandrost-5-ene
[Na+].[OH-]
sodium hydroxide
→
C[C@]12CC[C@H]3[C@@H]([C@@H](O)C=C4C[C@@H](O)CC[C@@]43C)[C@@H]1C[C@@H](O)[C@@H]2O
3β,7β,16α,17β-tetrahydroxyandrost-5-ene

Réactifs

C[C@]12CC[C@H]3[C@@H]([C@@H](O)C=C4C[C@@H](O)CC[C@@]43C)[C@@H]1C[C@@H](Br)[C@@H]2O
16α-bromo-3β,7β,17β-trihydroxyandrost-5-ene
[Na+].[OH-]
sodium hydroxide

Réactifs

Aucun

Solvants

CN(C)C=O
dimethylformamide

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Mode opératoire

16α-bromo-3β,7β,17β-trihydroxyandrost-5-ene (CLIII, X=Br) is reacted with sodium hydroxide in dimethylformamide to form 3β,7β,16α,17β-tetrahydroxyandrost-5-ene (CLXI)

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US05387583uspto-grants-1995_02