Réaction #356891

Équation de réaction

potassium carbonate

4-phenylphenol

6-chloro-1-hexanol

→

4-(6-hydroxyhexyloxy)phenylbenzene

Rendement 85.1%

Solvants

water

DMF

N,N-dimethylformamide

Conditions de réaction

Traitement

1. 1
   workup.ADDITIONwas added with constant stirring
2. 2
   workup.WAITto proceed for 12 hours under constant stirring
3. 3
   Filtrationthe precipitated solid was recovered by filtration
4. 4
   AutreThe resulting solid was then recrystallized from ethanol

Mode opératoire

17 g of 4-phenylphenol (0.1 mol) was dissolved in 120 mL of N,N-dimethylformamide (hereafter abbreviated as DMF), 15.2 g of potassium carbonate powder (0.11 mol) was added with constant stirring, and the mixture was then stirred for one hour while heating at 90° C. Subsequently, 6-chloro-1-hexanol (14.3 g, 0.11 mol) was added dropwise to the mixture, and the reaction was allowed to proceed for 12 hours under constant stirring. Following confirmation by gas chromatography that the peaks derived from the raw materials had disappeared, the reaction mixture was diluted with water, and the precipitated solid was recovered by filtration. The resulting solid was then recrystallized from ethanol, yielding 23 g of 4-(6-hydroxyhexyloxy)phenylbenzene (yield: 85%).

Source