Réaction #355740

Équation de réaction

2-fluoro-5-nitrotoluene

N-methylpyrrolidinone

2-aminoethoxyethanol

K2CO3

→

2-[2-(4-nitro-2-methylphenylamino)ethoxy]ethanol

Solvants

water

Conditions de réaction

Traitement

1. 1
   Températureafter cooling to room temperature
2. 2
   ExtractionThe resulting medium was extracted with ethyl acetate
3. 3
   Concentrationthe organic phase was then concentrated under vacuum

Mode opératoire

2 g of 2-fluoro-5-nitrotoluene were added to a solution of 20 ml of N-methylpyrrolidinone, 1.63 g of 2-aminoethoxyethanol and 2.14 g of K2CO3. The reaction medium was heated at 60° C. for 12 hours and, after cooling to room temperature, was then poured into a water and ice mixture. The resulting medium was extracted with ethyl acetate and the organic phase was then concentrated under vacuum. 2.2 g of 2-[2-(4-nitro-2-methylphenylamino)ethoxy]ethanol (13) were obtained.

Source