Réaction #354576

Équation de réaction

sodium thiocyanate

α, 2'-dichloro-4-biphenylylacetic acid

→

α-thiocyanato-2'-chloro-4-biphenylylacetic acid

Solvants

ethanol

Conditions de réaction

Traitement

1. 1
   FiltrationThe reaction mixture is filtered
2. 2
   Lavagewashed with absolute ethanol
3. 3
   AutreThe filtrate is evaporated to dryness
4. 4
   workup.DISSOLUTIONthe residue is dissolved in 250 ml
5. 5
   Lavageof ether and washed several times with water
6. 6
   SéchageThe ether is then dried
7. 7
   Autreevaporated to dryness

Mode opératoire

To a solution of 300 ml. of anhydrous ethanol and 0.15 moles of sodium thiocyanate is added 35 g. (0.12 moles) of α, 2'-dichloro-4-biphenylylacetic acid and stirred for 15 hours. The reaction mixture is filtered and washed with absolute ethanol. The filtrate is evaporated to dryness, the residue is dissolved in 250 ml. of ether and washed several times with water. The ether is then dried and evaporated to dryness to obtain α-thiocyanato-2'-chloro-4-biphenylylacetic acid.

Source