Réaction #3501

Équation de réaction

N-methoxy-2,4-dichlorobenzamide

potassium carbonate

propargyl bromide

N,N-dimethylformamide

→

propargyl N-methoxy-2,4-dichlorobenzimidate

Rendement 29.8%

Solvants

water

Conditions de réaction

Traitement

1. 1
   workup.ADDITIONwas added to the reaction solution
2. 2
   Extractionthe mixture was extracted with ethyl acetate
3. 3
   AutreThe extract was dried
4. 4
   Concentrationconcentrated
5. 5
   Autrepurified by silica gel column chromatography

Mode opératoire

1.0 g of N-methoxy-2,4-dichlorobenzamide, 0.75 g of potassium carbonate and 0.65 g of propargyl bromide were added to 10 ml of N,N-dimethylformamide, and the mixture was stirred for 3 hours. After completion of the reaction, water was added to the reaction solution, and the mixture was extracted with ethyl acetate. The extract was dried, concentrated and purified by silica gel column chromatography to obtain 0.35 g of propargyl N-methoxy-2,4-dichlorobenzimidate.

Source