Réaction #3444

Équation de réaction

1-([1,1'-biphenyl]-4-ylmethyl)-4-methoxy-2-methyl-1H-indole

BBr3

Cl2

→

1-([1,1'-biphenyl]-4-ylmethyl)-4-hydroxy-2-methyl-1H-indole

Rendement 77.4%

Conditions de réaction

Mode opératoire

By the method used in Example 1, Part D, 1.3 g (4.0 mmol) of 1-([1,1'-biphenyl]-4-ylmethyl)-4-methoxy-2-methyl-1H-indole was O-demethylated by treating it with 16 mL of 1M BBr3 /CH2 Cl2 to give 970 mg (77% yield) of crude 1-([1,1'-biphenyl]-4-ylmethyl)-4-hydroxy-2-methyl-1H-indole.

Source