Réaction #3442

Équation de réaction

1-([1,1'-biphenyl]-3-ylmethyl)-4-methoxy-2-methyl-1H-indole

BBr3

Cl2

→

1-([1,1'-biphenyl]-3-ylmethyl)-4-hydroxy-2-methyl-1H-indole

Rendement 87.0%

Conditions de réaction

Mode opératoire

By the method used in Example 1, Part D, 1.25 g (3.8 mmol) of 1-([1,1'-biphenyl]-3-ylmethyl)-4-methoxy-2-methyl-1H-indole was O-demethylated by treating it with 15.2 mL of 1M BBr3 /CH2 Cl2 to give 1.03 g (87% yield) of crude 1-([1,1'-biphenyl]-3-ylmethyl)-4-hydroxy-2-methyl-1H-indole.

Source