Réaction #343447

Équation de réaction

2-amino-4,6-dimethoxypyrimidine

2-methoxycarbonyl-3-thiophenesulfonyl isocyanate

→

Methyl 3 [[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl] aminosulfonyl]-2-thiophenecarboxylate

Solvants

acetonitrile

Conditions de réaction

Traitement

1. 1
   workup.DISSOLUTIONAll of the solid reactant dissolved and after twenty minutes
2. 2
   workup.STIRRINGof stirring a precipitate
3. 3
   Autreto form
4. 4
   FiltrationAfter two hours the mixture was filtered
5. 5
   Lavagethe solid which was washed with anhydrous ethyl ether, melted at 191°-193°
6. 6
   AutreThe infrared absorption spectrum
7. 7
   Autreabsorption peaks at 1730 and 1700 cm-1 consistent for the two carbonyl peaks in the desired product

Mode opératoire

To 1.5 g of 2-amino-4,6-dimethoxypyrimidine in 30 ml of anhydrous acetonitrile was added 2.7 g of 2-methoxycarbonyl-3-thiophenesulfonyl isocyanate with stirring at ambient temperature. All of the solid reactant dissolved and after twenty minutes of stirring a precipitate started to form. After two hours the mixture was filtered and the solid which was washed with anhydrous ethyl ether, melted at 191°-193°. The solid showed peaks by nuclear magnetic resonance spectroscopy at 4.0 ppm and 3.8 ppm for the methoxy groups, 6.0 ppm for the H of pyrimidine and 7.6 ppm for the hydrogens on thiophene. The infrared absorption spectrum showed absorption peaks at 1730 and 1700 cm-1 consistent for the two carbonyl peaks in the desired product.

Source