Réaction #342998

Équation de réaction

product

2-(Carbomethoxyfur-5-yl)benzenesulfonyl isocyanate

2-amino-4,6-dimethoxypyrimidine

DABCO

→

title compound

Rendement 93.2%

2-(2-Carbomethoxyfur-5-yl)-N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]benzenesulfonamide

Rendement 93.2%

Solvants

acetonitrile

Conditions de réaction

Traitement

1. 1
   FiltrationThe solid was filtered off
2. 2
   Lavagewashed with acetonitrile and 1-chlorobutane
3. 3
   Autredried at 60° in vacuo

Mode opératoire

Under a nitrogen atmosphere, a mixture of 2.5 g of the product of Example 3, 0.9 g of 2-amino-4,6-dimethoxypyrimidine, and a few crystals of DABCO in 15 ml of dry acetonitrile was heated at 50°-55° for 1 hour, then stirred at 25° overnight. The solid was filtered off, washed with acetonitrile and 1-chlorobutane, and dried at 60° in vacuo to give 2.5 g of the title compound, mp=215°-217° (d).

Source