Réaction #340999

ord-b33e2f7f71994dc394e4de6f8a27de11

Équation de réaction

CCOC(=O)CSc1cnc(NC(=O)N(C2CCCCCC2)C2CCCCC2)s1
[2-(3-Cycloheptyl-3-cyclohexyl-ureido)-thiazol-5-ylsulfanyl]-acetic acid ethyl ester
C1CCCC(NC2CCCCC2)CC1
cyclohexyl-cycloheptylamine
CCOC(=O)CS.Nc1cncs1
5-aminothiazole 2-mercaptoacetic acid ethyl ester
→
O=C(O)CSc1cnc(NC(=O)N(C2CCCCCC2)C2CCCCC2)s1
title compound
O=C(O)CSc1cnc(NC(=O)N(C2CCCCCC2)C2CCCCC2)s1
[2-(3-Cycloheptyl-3-cyclohexyl-ureido)-thiazol-5-ylsulfanyl]-acetic acid

Réactifs

CCOC(=O)CSc1cnc(NC(=O)N(C2CCCCCC2)C2CCCCC2)s1
[2-(3-Cycloheptyl-3-cyclohexyl-ureido)-thiazol-5-ylsulfanyl]-acetic acid ethyl ester
C1CCCC(NC2CCCCC2)CC1
cyclohexyl-cycloheptylamine
CCOC(=O)CS.Nc1cncs1
5-aminothiazole 2-mercaptoacetic acid ethyl ester

Réactifs

Aucun

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Traitement

  1. 1
    AutreHydrolysis

Mode opératoire

[2-(3-Cycloheptyl-3-cyclohexyl-ureido)-thiazol-5-ylsulfanyl]-acetic acid ethyl ester prepared as described in general procedure (A) using cyclohexyl-cycloheptylamine and 5-aminothiazole-2-mercaptoacetic acid ethyl ester. Hydrolysis using general procedure (F) gave the title compound.

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US07872139B2uspto-grants-2011_01