Réaction #339873

Équation de réaction

hydrochloric acid

sodium boron hydride

water

methyl 2-hydroxy-3,3,3-trifluoro-2-trifluoromethylpropionate

→

3,3,3-trifluoro-2-trifluoromethyl-1,2-propane diol

Rendement 96.0%

Solvants

diethyl ether

Conditions de réaction

Traitement

1. 1
   workup.STIRRINGThe mixture was stirred for 10 hours
2. 2
   Autreto quench
3. 3
   Autrethe reaction
4. 4
   AutreAn organic layer was separated from the reaction mixture
5. 5
   Concentrationconcentrated
6. 6
   workup.DISTILLATIONdistilled

Mode opératoire

To a mixture of 25.0 g of sodium boron hydride, 500 g of water, and 500 g of diethyl ether, with stirring, 100 g of methyl 2-hydroxy-3,3,3-trifluoro-2-trifluoromethylpropionate was added dropwise. The mixture was stirred for 10 hours, after which hydrochloric acid was added to quench the reaction. An organic layer was separated from the reaction mixture, concentrated, and distilled, obtaining 83.9 g of 3,3,3-trifluoro-2-trifluoromethyl-1,2-propane diol (yield 96%).

Source