Réaction #339592

Équation de réaction

3,6-diethoxy-2-{2-[8-(2-methoxyethoxy)naphthalen-2-ylmethyl]-3-methylbutyl}-2,5-dihydropyrazine

HCl

sodium bicarbonate

acetonitrile

→

Ethyl 2-amino-4-[8-(2-methoxyethoxy)naphthalen-2-ylmethyl]-5-methylhexanoate

Conditions de réaction

Traitement

1. 1
   Autreat room temperature
2. 2
   Extractionthe mixture is extracted with dichloromethane (3×)
3. 3
   LavageThe combined organic phases are washed with water (3×)
4. 4
   Séchagedried with sodium sulphate
5. 5
   Concentrationconcentrated by evaporation

Mode opératoire

A solution of 1.57 g of 3,6-diethoxy-2-{2-[8-(2-methoxyethoxy)naphthalen-2-ylmethyl]-3-methylbutyl}-2,5-dihydropyrazine in 14 ml of acetonitrile at room temperature is admixed with 14 ml of 1N HCl. After 30 minutes, the reaction mixture is poured into a stirred mixture of 15 ml of saturated aqueous sodium bicarbonate solution and 15 g of ice, and the mixture is extracted with dichloromethane (3×). The combined organic phases are washed with water (3×), dried with sodium sulphate and concentrated by evaporation. The crude title compound is identified on the basis of the Rf value from the residue.

Source