Réaction #339588

Équation de réaction

tert-butyl {3-[8-(2-methoxyethoxy)naphthalen-2-ylmethyl]-4-methyl-1-oxiranylpentyl}carbamate

piperidine

→

tert-Butyl {1-(1-hydroxy-2-piperidin-1-ylethyl)-3-[8-(2-methoxyethoxy)naphthalen-2-ylmethyl]-4-methylpentyl}carbamate

Solvants

isopropanol

Conditions de réaction

Traitement

1. 1
   AutreOn completion of reaction (TLC monitoring)
2. 2
   Concentrationthe reaction mixture is concentrated by evaporation
3. 3
   Extractionextracted with tert-butyl methyl ether (2×)
4. 4
   LavageThe combined organic phases are washed successively with water and brine
5. 5
   Séchagedried over sodium sulphate
6. 6
   Concentrationconcentrated by evaporation

Mode opératoire

A solution of 0.23 g of tert-butyl {3-[8-(2-methoxyethoxy)naphthalen-2-ylmethyl]-4-methyl-1-oxiranylpentyl}carbamate in 4 ml of isopropanol and 0.99 ml of piperidine is stirred at 70° C. On completion of reaction (TLC monitoring), the reaction mixture is concentrated by evaporation, and the residue is admixed with water and extracted with tert-butyl methyl ether (2×). The combined organic phases are washed successively with water and brine, dried over sodium sulphate and concentrated by evaporation. The title compound is identified on the basis of the Rf value from the residue by means of flash chromatography (SiO2 60F).

Source