Réaction #339550

Équation de réaction

hydrogen

acetic acid 4-(4-methoxy-but-1-ynyl)-pyridin-3-yl ester

quinoline

→

title compound

Acetic acid 4-(4-methoxy-butyl)-pyridin-3-yl ester

Solvants

ethyl acetate

Conditions de réaction

Traitement

1. 1
   AutreThe catalyst is removed by filtration
2. 2
   Autrethe solvent is evaporated

Mode opératoire

To a degassed solution of 9.9 mmol acetic acid 4-(4-methoxy-but-1-ynyl)-pyridin-3-yl ester and 0.51 mmol quinoline in 230 ml ethyl acetate is added 0.56 mmol 10% Pd/C. The suspension is vigorously stirred under an atmospheric pressure of hydrogen for 2 hours. The catalyst is removed by filtration and the solvent is evaporated. The title compound is obtained from the residue by means of flash chromatography (SiO2 60F) and identified based on its Rf value.

Source